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The SIR will alwaysbe 1 in the standard population, <1 indicates that the rate in one group islower than expected, and >1 that it is higher. The -lactamases may be presentin low quantity but strategically located peri-plasmically (as in gram-negative bacteria) so thatthe drug is inactivated soon after entry, or maybe elaborated in large quantities (by gram-positive bacteria) to diffuse into the medium anddestroy the drug before entry.(ii)Chloramphenicol acetyl transferase is acqui-red by resistant E

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